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KMID : 0386520000080020093
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Research Institute of Korean Medicone
2000 Volume.8 No. 2 p.93 ~ p.106
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Study on Antitumor Effect of Kamicheungyeolhaedogtang(KCHT)(Ⅰ)
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金圭/Kim, Gyu
金東熙/崔奉均/金聖勳/Kim, Dong-Hee/Choi, Bong-Gyoon/Kim, Sung-Hoon
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Abstract
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To evaluate the antitumor activity and antimetastatic effects of Kamicheungyeolhaedog tang(KCHT), studies were done experimentally.
The results were obtained as follows:
1. KCHT extracts exhibited a significant cytotoxicity against A549, , SK-MEL-2, SK-OV-3, and B16-BL6 cell lines.
2. KCHT extracts showed significant inhibitoty effect on DNA topoisomerase I
3. The T/C% was 145.8% in KCHT treated group in S-180 bearing ICR mice.
4. KCHT extracts exhibited efficient affect adhesive effect of A549, B16-BL6 cell to complex extracellular matrix.
5. In vitro neovascularization assays, angiogenesis was insignificantly inhibited in KCHT treated group as compared with control group.
These results suggested that KCHT extracts might be usefully applied for prevention and treatement of cancer.
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KEYWORD
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